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Schmidt Meister
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The sleepy Biden Administration needs to do it's own operation warp speed for Pfizer's Paxlovid.  The drug is approved, but in short supply.  Getting manufacturing facilities to mass produce this drug could benefit from the same sort of fast tracking effort that Trump was able to make with the vaccine.  But, alas, this administrations seems to be clueless about just about every issue of importance. 

 

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Pfizer reported that its pill (combined with a low dose of ritonavir, an HIV drug) showed 89% efficacy in preventing hospitalization and death in the high-risk patients it studied.

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And unlike vaccines or monoclonals, the drugs don’t create protective antibodies. Instead, they attack the virus itself.   Pfizer’s drug blocks an enzyme needed by the virus to reproduce.

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The Pfizer drug cuts the risk of hospitalization or death in high-risk adults by 89%.

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But there’s a shortage, so they’re only offered to people who meet all three of these criteria: positive test results, symptoms of mild to moderate COVID-19 illness and high risk for progressing to severe disease.

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“We all have patients that we would like to treat, but we just can’t, based on our supply,” said Katherine Yang, an infectious diseases pharmacist specialist at UCSF Health.

Why is there so little supply?

The mass production of small-molecule drugs is logistically complicated, according to medicinal chemist Derek Lowe in the journal Science. The drugs are produced from a large variety of chemicals, called reagents, that come from offshore suppliers, mostly in China. And production must be done on an industrial scale. For instance, the manufacture of 10 million courses of Paxlovid requires about 16.5 tons of material, he estimates.

“There’s a shortage of the stuff that’s used to make the stuff,” he wrote. “That’s how it goes in the fine chemical business – there’s a compound that no one really cares much about – until they do.”

Federal decision-making is also being blamed for the shortage. Early on, the U.S. didn’t place an order for the mass production of pills, like it did with vaccines, said Dr. Eric Topol, founder and director of the Scripps Research Translational Institute in La Jolla.

When the pill showed early promise, “Pfizer approached the administration to say ‘Would you like to put in big orders for Paxlovid?’” said Topol. Trusting in the power of vaccines, “it declined.”

 

https://www.mercurynews.com/2022/01/16/new-covid-drugs-are-here-you-just-need-to-find-them/

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At Least 25 Federal Agencies Are Tracking Religious Exemption Requests

"At least 25 federal agencies have implemented a system to track religious exemption requests for mandated vaccines, according to a review of Federal Register notices by The Epoch Times.

The agencies include the departments of Justice, Health and Human Services, Housing and Urban Development, Transportation, the Treasury, the Social Security Administration, the Federal Election Commission.

The Heritage Foundation, a conservative group, earlier this week found that 19 agencies were either considering or have already implemented the tracking system. The group warned that the system may be a test pilot plan to monitor all federal workers."

https://www.technocracy.news/at-least-25-federal-agencies-are-tracking-religious-exemption-requests/

https://www.theepochtimes.com/at-least-19-federal-agencies-consider-tracking-religious-exemption-requests_4222961.html

"Due to the Biden administration’s choice of the little-known Pretrial Services Agency to implement the database, The Heritage Foundation called the system a “test run” for a nationwide database of all religious exemption requests made by federal workers. The Pretrial Services Agency gathers information and makes recommendations about newly arrested defendants in the federal criminal system."

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